Analysis Of Human Genetic Linkage

Book Description

The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book.

New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.

Praise for the previous edition:

"Overall the book achieves an excellent compromise between presenting important conclusions and working out the details... Analysis of Human Genetic Linkage is a good book that has been made substantially better. It continues to be the standard reference for every linkage analyst's library and to provide an excellent introduction for the interested beginner with a background in the biological or mathematical sciences."--American Journal of Human Genetics

Customer Reviews:

Too many mistakes!.......2001-12-16

I can not believe that One can make so many mistakes for such a 400 pages book. On page 12, there are 2 major mistakes which will lead anyone who is not an expert in this area to hell.

THE book........2000-04-07

This is THE book on the subject. The bible of the field by a master.

Bivariate linkage analysis of the insulin resistance syndrome phenotypes on chromosome 7q.: An article from: Human Biology

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Bivariate linkage analysis of the insulin resistance syndrome phenotypes on chromosome 7q.: An article from: Human Biology
Donna M. Lehman , Rector Arya , John Blangero , Laura Almasy , Sobha Puppala , Thomas D. Dyer , Robin J. Leach , Peter O'Connell , Michael P. Stern , and Ravindranath Duggirala
Manufacturer: Thomson Gale
ProductGroup: Book
Binding: Digital

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Book Description

This digital document is an article from Human Biology, published by Thomson Gale on April 1, 2005. The length of the article is 5500 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: KEY WORDS: METABOLIC SYNDROME, INSULIN RESISTANCE SYNDROME, VARIANCE COMPONENT ANALYSIS, PLEIOTROPY, D7S653, MEXICAN AMERICANS, PEDIGREES.

Citation Details
Title: Bivariate linkage analysis of the insulin resistance syndrome phenotypes on chromosome 7q.
Author: Donna M. Lehman
Publication: Human Biology (Magazine/Journal)
Date: April 1, 2005
Publisher: Thomson Gale
Volume: 77 Issue: 2 Page: 231(16)

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Haplotype Analysis of the Apolipoprotein E and Apolipoprotein C1 Loci in Portugal and Sao Tome e Principe (Gulf of Guinea): Linkage Disequilibrium Evidence ... Included): An article from: Human Biology

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Haplotype Analysis of the Apolipoprotein E and Apolipoprotein C1 Loci in Portugal and Sao Tome e Principe (Gulf of Guinea): Linkage Disequilibrium Evidence ... Included): An article from: Human Biology
Susana Seixas , Maria Jesus Trovoada , and Jorge Rocha
Manufacturer: Wayne State University Press
ProductGroup: Book
Binding: Digital

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Book Description

This digital document is an article from Human Biology, published by Wayne State University Press on December 1, 1999. The length of the article is 2208 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: KEY WORDS: HAPLOTYPE ANALYSIS, APOE, APOC1, PORTUGAL, SAO TOME

Citation Details
Title: Haplotype Analysis of the Apolipoprotein E and Apolipoprotein C1 Loci in Portugal and Sao Tome e Principe (Gulf of Guinea): Linkage Disequilibrium Evidence That APOE*4 Is the Ancestral APOE Allele.(Statistical Data Included)
Author: Susana Seixas
Publication: Human Biology (Refereed)
Date: December 1, 1999
Publisher: Wayne State University Press
Volume: 71 Issue: 6 Page: 1002

Article Type: Statistical Data Included

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Inferring Microevolutionary Patterns from Allele-Size Frequency Distributions of Minisatellite Loci: A Worldwide Study of the APOB 3' Hypervariable Region Polymorphism.: An article from: Human Biology

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Inferring Microevolutionary Patterns from Allele-Size Frequency Distributions of Minisatellite Loci: A Worldwide Study of the APOB 3' Hypervariable Region Polymorphism.: An article from: Human Biology
Giovanni Destro-bisol , Cristian Capelli , and Michele Belledi
Manufacturer: Wayne State University Press
ProductGroup: Book
Binding: Digital

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Book Description

This digital document is an article from Human Biology, published by Wayne State University Press on October 1, 2000. The length of the article is 6977 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Inferring Microevolutionary Patterns from Allele-Size Frequency Distributions of Minisatellite Loci: A Worldwide Study of the APOB 3' Hypervariable Region Polymorphism.
Author: Giovanni Destro-bisol
Publication: Human Biology (Refereed)
Date: October 1, 2000
Publisher: Wayne State University Press
Volume: 72 Issue: 5 Page: 733

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Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes.: An article from: Human Biology

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Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes.: An article from: Human Biology
Laura Almasy , David L. Rainwater , Shelley Cole , Michael C. Mahaney , John L. Vandeberg , James E. Hixson , Michael P. Stern , Jean W. MacCluer , and John Blangero
Manufacturer: Thomson Gale
ProductGroup: Book
Binding: Digital

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Book Description

This digital document is an article from Human Biology, published by Thomson Gale on February 1, 2005. The length of the article is 3488 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: KEY WORDS: HEPATIC LIPASE GENE, LIPC, HDL CHOLESTEROL, LDL CHOLESTEROL, LIPOPROTEIN DIAMETER, GENOME-WIDE SCREEN, HERITABILITY.

Citation Details
Title: Joint linkage and association analysis of the hepatic lipase promoter polymorphism and lipoprotein size phenotypes.
Author: Laura Almasy
Publication: Human Biology (Magazine/Journal)
Date: February 1, 2005
Publisher: Thomson Gale
Volume: 77 Issue: 1 Page: 17(9)

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A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19.(Statistical Data Included): An article from: Human Biology

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A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19.(Statistical Data Included): An article from: Human Biology
Lisa J. Martin , John Blangero , Jeffrey Rogers , Michael C. Mahaney , James E. Hixson , K. Dee Carey , and Anthony G. Comuzzie
Manufacturer: Wayne State University Press
ProductGroup: Book
Binding: Digital

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ASIN: B0008IMCS2
Release Date: 2005-07-28

Book Description

This digital document is an article from Human Biology, published by Wayne State University Press on December 1, 2001. The length of the article is 6002 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: Abstract Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome l9pl3.2, showed marginal evidence of linkage with a lod ([log.sub.10] of the odds in favor of genetic linkage) score of 1.95 (0.014). This region contains several potential candidate genes including PKA (protein kinase, cAMP-dependent, catalytic [alpha]) and the gene pair JUN-B and JUN-D. This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio.

Citation Details
Title: A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19.(Statistical Data Included)
Author: Lisa J. Martin
Publication: Human Biology (Refereed)
Date: December 1, 2001
Publisher: Wayne State University Press
Volume: 73 Issue: 6 Page: 787(14)

Article Type: Statistical Data Included

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Analysis of Human Genetic Linkage. Revised

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Analysis of Human Genetic Linkage. Revised
Jurg Ott
Manufacturer: Johns Hopkins
ProductGroup: Book
Binding: Hardcover
ASIN: B000LZITQQ

Book Description

Residents and out-of-state visitors alike will find hundreds of fun, and often free, things families can see and do in the Centennial State, from visiting Raging Rivers Water Park in Grafton to exploring Starved Rock State Park in Utica.

Fun with the Family in Illinois, 3rd: Hundreds of Ideas for Day Trips with the Kids

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Handy, handy, handy

Fun with the Family in Illinois, 3rd: Hundreds of Ideas for Day Trips with the Kids
Lori Meek Schuldt
Manufacturer: Globe Pequot
ProductGroup: Book
Binding: Paperback

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ASIN: 0762707577

Book Description

Here's the inside information on all the family-friendly fun to be had in the Centennial State. Fun with the Family in Illinois leads the way to amusement parks, hiking trails, zoos and aquariums, children's museums, festivals, parks, and much more.

Written by a parent, for parents, this opinionated, personal, and easy-to-use guide has the best things to see and do to keep the kids busy and happy for an hour, a day, or a weekend - a guaranteed antidote to vacation boredom.

This guide includes up-to-the-minute information on Illinois's family attractions, detailed maps, quick reference icons, age-appropriate guidelines, kid-friendly restaurants and places to stay.

Customer Reviews:

Handy, handy, handy.......2000-07-12

My Dad and Grandpap were coming up for a visit this summer, and my wife used this book to find things to do during their visit. We found lots of things, including the Illinois Railway Museum which goes along with their love for trains and everyone had a wonderful time.

Then, the next week, we found ourselves in western Illinois with nothing to do one day, so we pulled out this book and found the John Deere Pavilion in Moline. My 2 1/2 year old son loved climbing in the tractors!

We would never have found these places without this book! What a great idea!

Book Description

The Shevvingtons are perfect. Mr. Shevvington is the charming, handsome principal of Christina's school. His wife is a dedicated English teacher. When the Autumn fog rolls over the coast, Christian and Anya begin boarding at the Shevvington's home, where Christina discovers that nothing is as it seems. Anya is slowly losing her mind, and Christina knows the Shevvingtons are behind it. But who will take her word against that of the Shevvingtons? This is book one in the LOSING CHRISTINA series.

Customer Reviews:

Young Girl Fights Back.......2007-06-20

Christina has lived her entire life on a tiny island off the coast of Maine. She loves it there and is happy with her life. This year she is especially happy, as it is the first year she will be able to attend the junior high and senior high school on the mainland. She will travel there in September with eighteen-year-old Anya, sixteen-year-old Benj, and fourteen-year-old Michael, the only other island children old enough to need to go to the mainland school. All four will board at an inn that has recently been bought by the new principal of the school and his wife, the seventh-grade English teacher.

Things are bad right from the beginning. The principal and his wife seem needlessly cruel to the children, especially Christina who can't seem to do anything right and who argues with rules she thinks are unfair. Little by little she notices, though, that there is something truly sinister about the couple they are living with. They seem to take pleasure in humiliating children and breaking their spirits. Christina suspects that they are behind Anya's mental collapse, and she feels she may be next unless she can convince someone of how dangerous these people are.

I liked the strength of Christina's character. She said what was on her mind, stuck up for herself and for others, and was never afraid enough to give in. I didn't like that Christina's parents didn't believe anything that she said. It seemed as though they should have at least listened to her and thought about her point of view.

Fog by Caroline B. Cooney.......2007-02-23

The book Fog, by Caroline B. Cooney, is about a group of kids, Christina, Anya, Ben, and Michael,that are taken up by a mainland principal to go to school. They are from an island on the coast called Burning Fog Island. The mainland kids don't like islanders very much. Everything seems to be going well until Anya starts to lose her mind. Christina knows that the principal and his wife are behind it. They try to force Christina towards the same fate but they fail. Christina also saves Anya from her mental and physical death. She convinces Anya, at the last second, to turn away from the principal and come towards her friends. This book was great because of its very suspenseful pages, perfect story, and very realistic characters.

This book was extremely suspenseful and seems to beg you to turn the page. Every word seems more grabbing than the last. For example, when Anya is about to jump off a bridge to "sacrifice" herself to the sea, which is also an example of how she almost physically died and how she is going insane, you couldn't wait to see what happened next. Another example, is when you actually discover that Anya is going insane. You are so interested that you want to read what her fate is.

This book, also, seems to have a perfect storyline. Everything molds together when you discover that the principal is behind all of this. It also leaves you wondering how they did it. This encourages you to read the next book. The storyline, also, is very interesting. Especially at intense parts, such as the bridge scene.

Lastly, I liked this book because of its very real characters. It almost seems like the characters are popping out at you because they do realistic things. Another thing, is that the setting blends with the characters' personalities. For example, the main characters are from an island, so they are very tough and stubborn. Some kids from the mainland seem to get everything they want so they are mean to those who don't. Even the kids that are teased are always depressed and don't talk to others.

My final reason for liking this book is because of its position in good versus evil. It shows this when Christina ruins the principal's plans and "defeats" them. It also shows this when Christina "handles" the bullies at her school. I would recommend this book to anyone. I liked this book because of its position in good versus evil, realistic characters, suspenseful pages, and almost perfect story.

C. Copeland

Almost an incredible story.......2006-09-15

I almost had a hard time believing this could be possible. It's actually a good sense of horror as it shows the influence whether good, or bad adults have on children. Parents the fact that you're doing everything possible to have the best for you children doesn't necessarily mean that they will have the best. We as parents can only remember to look within ourselves, and make sure we're doing everything to let our children know we love them, and want to do right by them. This shows parents looking outside of themselves by sending Christina to school on the mainland of Maine, and entrusting the Shevvfords to care for her while she goes to school there on the mainland, but as soon as she gets there weird things begin to happen. Christina is with 3 other children, and they are 17 year old Avra, 16 year old Benj, 14 year old Michael, and Christina's 13. Avra's almost convinced the the sea wants to take one of them, and Christina's convinced that Shevvford's are up to no good, but due to New England stoicism, and the fact that the Shevvfords are that good at convincing the world that they have nothing but the best intentions for the children Christina has a hard time finding an audience, and for the most part not being able to fit in. It's not that they don't believe her it's just that they're so busy with thier own lives that they don't want the stress of finding out the truth, or if that was true about the dead bodies, and disappearance of 2 other students, and not to mention getting people to believe what's being said. I know that children getting to get parents to slow down, and realize that everything is not all black and white, but more complex, and children need to be believed when they speak the unbelievable, and etc. etc. I just look back on this, and can certainly feel the parents were in the wrong by not listening to their children. This is something that all parents can take n note of.

Worst literary effort I have seen.......2006-03-20

The book starts out confusing, uninteresting, and poorly written and remains that way throughout. Charachters are completely undeveloped and poorly executed. I would not reccommend this book to anyone.

Nowhere To Run.......2005-07-11

FOG is a top thriller!
Evil surrounds Christina in her new home and seems to drain the life and spirit out of the girls who live in it.
Headstrong Christina fights against this, but her biggest challenge is her struggle to convince adults of the evil that exists.
As in most good YA thrillers, they refuse to listen or believe her.

Book Description

The self-regulation of fish populations and why some fish stocks flourish and then die away are questions that have fascinated fisheries scientists for decades. In this account, David Cushing shows how the fate of fish larvae, which live close to the centers of production in the sea, has a crucial effect on population regulation. He shows how the timing and development of tidal fronts in particular regions have profound implications for fish and plankton production, which in turn affects whether or not enough of the fish larvae live to adulthood. One of the most interesting points made by the author is how vulnerable fish populations are to climate change, and it is only by understanding these processes that we can hope to recognize the implications of global climate change on marine populations. This book will be essential reading for all those interested in marine ecology and fisheries biology.

Book Description

Based on a Short Course sponsored by Canada's Petroleum Recovery Institute. The first book to focus on the occurrence of emulsions in the petroleum industry. Brings together contributions from a wide range of experts. Provides an up-to-date examination of the nature, occurrence, handling, formation, and breaking of petroleum emulsions. Topics covered include emulsion stability; characterization techniques; rheology of emulsions, and flow properties of emulsions in pipes and porous media, well-head productions, and industrial process streams. Using the fundamental concepts, and based on commercial and pilot-scale experiences, Also shows how to approach making desirable emulsions, transporting and handling them, and how to approach breaking undesirable emulsions.

Book Description

This volume is based on proceedings held during the DIMACS workshop on Randomization Methods in Algorithm Design in December 1997 at Princeton. The workshop was part of the DIMACS Special Year on Discrete Probability. It served as an interdisciplinary research workshop that brought together a mix of leading theorists, algorithmists and practitioners working in the theory and implementation aspects of algorithms involving randomization.

Randomization has played an important role in the design of both sequential and parallel algorithms. The last decade has witnessed tremendous growth in the area of randomized algorithms. During this period, randomized algorithms went from being a tool in computational number theory to finding widespread applications in many problem domains.

Major topics covered include randomization techniques for linear and integer programming problems, randomization in the design of approximate algorithms for combinatorial problems, randomization in parallel and distributed algorithms, practical implementation of randomized algorithms, de-randomization issues, and pseudo-random generators. This volume focuses on theory and implementation aspects of algorithms involving randomization. It would be suitable as a graduate or advanced graduate text.

Book Description

For composition and introduction to literature courses, The Riverside Anthology of Literature has long been praised for its rich variety of selections, its interwoven commentary, its eloquent editorial prose, its unobtrusive apparatus, and its organizational flexibility. To acquaint students quickly with the specific qualities of a genre, each section now opens with six short selections that focus on a particular theme for easy comparison and contrast.

Customer Reviews:

The Kind of Book You Buy Because You Have To........2005-12-29

This is the sort of book you buy at a high price as a text for a college class, then try to get as much for it in resale as possible. If you cannot get enough out of the resale to make you feel comfortable, you simply stick it on a shelf for the next 40 years. From time to time, you (may??) take it down to read a particular selection. But even if you don't, just owning it makes you look a little more sophisticated.

I know my comments sound cynical, but who buys such a book for the simple joy of reading? Some of the selections are powerful. Some of the selections are popular. Some of the selections are of literary significance, but not enough of them to make the book worth the price.

Now . . . if they would have added Lord Byron, I would have changed my mind. ;-)

Nice Book, But Doesn't Really Contain Anything MOre Than Literatures.......2005-08-10

The book is like most other literature books, this one was meant more for college. Containing mainly poems, plays, and short stories written by some well known writers that some of you could probably feel familiar with more or less. The book mainly delievers what it is about and therefore its satisfactory. The book also talks about the author such as dates and the other books in their collection of written material. However, I was hoping there would be more than simply this, like going in depth and explaining the literature. Finding written work is easy, finding a review that explains it when needed is a lot harder. But I guess with this, they can't really ask us many of the questions there. Maybe they should have an answer key.

An overall great book.......1998-04-10

This book has some great poetry in it as well as some really good plays and short stories. I definitely reccomend it as a good addition to any bookshelf.

Hunt Riverside Anthology Literature Third Edition Plus Trimmer Guide to MLA Document Sixth Edition

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Hunt Riverside Anthology Literature Third Edition Plus Trimmer Guide to MLA Document Sixth Edition

Manufacturer: Houghton Mifflin Company
ProductGroup: Book
Binding: Hardcover

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books

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ASIN: 0618471952

The Riverside Anthology of Literature, Third Edition and Guide to M L a Document, Sixth Edition and Practical Strategies for Critical Thinking

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The Riverside Anthology of Literature, Third Edition and Guide to M L a Document, Sixth Edition and Practical Strategies for Critical Thinking
Hunt
Manufacturer: Houghton Mifflin Company
ProductGroup: Book
Binding: Hardcover

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ASIN: 0618405593

Barton Contemporary Handbook Literature Terms Second Edition+hunt Riverside Anthology Literature Third Edition

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Barton Contemporary Handbook Literature Terms Second Edition+hunt Riverside Anthology Literature Third Edition
Hunt
Manufacturer: Houghton Mifflin Company
ProductGroup: Book
Binding: Hardcover

Riverside Anthology Literature Student Paperback, Third Edition

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Riverside Anthology Literature Student Paperback, Third Edition
Hunt
Manufacturer: Houghton Mifflin Company
ProductGroup: Book
Binding: Paperback

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ASIN: 0395760739

The Riverside Anthology of Literature and Student Paper Packet, Third Edition

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The Riverside Anthology of Literature and Student Paper Packet, Third Edition
Hunt
Manufacturer: Houghton Mifflin Acadmeic (NR)
ProductGroup: Book
Binding: Hardcover
ASIN: 0618353631

Riverside Anthology of Literature Third Edition

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Riverside Anthology of Literature Third Edition
Douglas Hunt
Manufacturer: Houghton Mifflin College Div
ProductGroup: Book
Binding: Hardcover
ASIN: B000J4ZO1M

Riverside Anthology of Literature, Third Edition and Practical Strategies for Critical Thinking and

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Riverside Anthology of Literature, Third Edition and Practical Strategies for Critical Thinking and
Hunt
Manufacturer: Houghton Mifflin (NR)
ProductGroup: Book
Binding: Hardcover
ASIN: 0618310878

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