Ionic Channels of Excitable Membranes

Book Description

Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded Third Edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.

Customer Reviews:

Excellent and useful text........2006-11-17

This text is an encyclopedia of information from kinetics to structure to interactions. It's got a reserved space on my academic bookshelf.

Destined to become an Oprah Book Club selection.......2005-12-08

Some books have opening sentences that grab you in an instant. "Call me Ishmael." "It was the best of times, it was the worst of times." And now, Hille joins the list of authors to reach out and grab us, with the awe-inspiring "Ion channels are macromolecular pores in cell membranes."

Even after my fifth reading, that line still gives me the shivers.

But it takes more than a brilliant opening to make a great book, and Hille delivers. From a distinctly jaunty derivation of the Nernst equation to the page-turning thrills of non-stationary fluctuation analysis, the book is hard to put down. It does bog down a little in Chapter 10, "Elementary Properties of Ions in Solution"--after all, is there anyone who isn't already aware of the fundamentals of electrodiffusion? But this is really a minor trifle in an otherwise masterful work.

It's just a matter of time before Oprah gives this book a nod; buy it now and avoid the rush!

Keeps getting better with each Edition.......2002-03-27

This book is a must-have for anyone working with excitable cells, be they experimentalists or modelers. It's a great reference book; everything is clearly indexed and almost compulsively cited. I've been using this book since its first edition, and it just keeps getting better each time.

Rara avis.......2002-02-09

This classic deserves all the praise it gets. It is an excellent introduction to the molecular biology of channels, told with an eye to history as well as science.

A classic. Still authoritative........2001-08-13

This is an authoritative textbook on ion channels that is often quoted in numerous textbooks in neurophysiology. Hille himself has contributed a lot in this field. The Hogkin-Huxley model is the de facto standard model in neurophysiology but certain things about neurons cannot be explained only with voltage-controlled sodium and potassium channels. With the patch-clamp technique, we have found a way to explore other interesting channles. To remind you, there are a world of ion channels! Hille's textbook show there are indeed a variety of channels most of which are poorly understood. As a reviewer below has commented, it also gives a unique insight into the history of neural membrane research. Concepts are explained with clearity. Details measurement techniques.

Amazon.com

New York Literary Lights is an encyclopedic collection of New York writers, their works, haunts, glories, and foibles. Meticulously researched and written with a sensitivity for the nuances of character, William Corbett reveals that Edna St. Vincent Millay lived in a house seven feet six inches wide; Russian immigrant Irving Berlin once said, "Everybody ought to have a Lower East Side in their life;" Jack Kerouac entered Columbia University on an athletic scholarship; Carson McCullers's birth name was Lula Carson Smith; and playwright Edward Albee found the name for his famous play, Who's Afraid of Virginia Woolf? scrawled on the mirror of a 10th Street bar.

Covering not only writers, but publishers, agents, magazines, bookstores, libraries, neighborhoods, and institutions, Corbett has met his goal of allowing the reader to appreciate, but not get lost in, the past--for New York thrives on the "rhythm of unceasing change." From the Academy of American Poets to Louis Zukofsky, hundreds of entries bring a freshly humble view of some of the biggest names in writing history. Whether you're seeking history, reference, or travel guide, Corbett's collection will satisfy. As Russell Banks says, "Reading it is like taking a leisurely stroll through the history of writing in New York City alongside a brilliant local historian who is as droll and sharp as he is learned." --Kathryn True

Book Description

William Corbett takes an expansive look at the ghosts, the landmarks, and the current denizens who make New York City so popular with the literary crowd. Ranging from Paul Auster to Zora Neale Hurston, from the Algonquin Round Table to the Nuyorican Poets Café, from Edgar Allan Poe to the Beat Generation, Corbett takes us on a dizzying ride through the literary highlights of New York.

Illuminating a city rich in famous writers against a combustible mixture of cultures and commerce, Corbett shows us how New York's multifaceted literary present has emerged from its constantly evolving past. New York Literary Lights travels through both time and place to provide an altogether enlightening, entertaining hybrid of history, gossip, and reference book.

Customer Reviews:

In Manhattan, surrealism is invisible.......1999-03-11

I remember the first time I saw New York. I was with my parents and we drove down through Pennsylvania from Canada, over the Susquehanna and into New Jersey. As we came around the turnpike, I recognized a city scape rising up over my left shoulder. Through the dusty car window and the haze, perspective was compressed and the distant city looked like jutting grey teeth. Emotionally I realized it was THE CITY, before I could make sense of the angle. It didn't fit with all the t.v. vistas and documentary pictures I had been raised on. It was unique, and it was fresh and it was my discovery.

As years go by and a once distant and monumental city becomes rationalized by repetitive experience, it is easy to lose the first sense of discovery, that dreamy feeling of seeing a great city for the first time.

"New York: Literary Lights" restores that magical quality. The book is an alphabetical listing of most of the great writers, publishers and writing haunts and events that have shaped the modern american mythos. More than just a back to back of mini-biographies, it is a secret map of the vital human side of New York. Streets that had begun to fade jumped back to life for me when I read that one of my favourite writers lived or worked there. The biographies are primarily about writers, but weave a rich fabric that depicts the literary history of New York. As I read deep into the book I found myself flipping back and forth, trying to pick up the trail of a place, or an event and its recurrant impact on New York literature. The writing is deft and chatty, the kind of writing that satisfies like gossip, but stays in mind much longer.

Although some of the stories and characters are legendary and quintessentially Gotham, like, say, Hart Crane, Norman Mailer, or the bar where Dylan Thomas took his last twelve drinks, the bulk of the book is deeper and more penetrating. There are several excellent entries on the Harlem scene, as well as the Jewish scene before and after the second world war. And I learned much about the generous nature of Nathaniel West. The merit of the book however, is Corbett's ability to go beyond the merely encycopedic- to bring out aspects or facts about a writer's life that I did not know. I learned more about people I thought I knew such as F. Scott Fitzgerald and Edgar Allan Poe.

Although I did not expect such devices, there is an excellent sectional map of Manhattan and Brooklyn which details the districts in which famous writers worked. As well, there is a nice glossary of quotes about New York, containing both the old familiar ones such as Hemingway's "Literary New York is a bottle of tapeworms trying to feed on each other" to Rem Koohaus' "In Manhattan, surrealism is invisible".

I managed to read this book before my last trip to New York. I regret this action, because if I had saved it, I could have extended the inevitable imaginal travel that takes place only when you have physically left a place behind.

I recommend this book highly, both as city guide of sorts and as a great armchair trip.

Book Description

When it’s time to start thinking about college, which campuses do New York City’s five hottest guys visit first? Ones where the girls outnumber the guys, obviously. On a road trip to Vassar, Jonathan is astonished to discover that his brother, Ted, is now considered cool. Mickey decides to turn the camera on himself—sans clothing. Arno finds his first love . . . he just needs to figure out where she went. Patch is searching for the perfect college for himself and Greta—but are they destined to be together? And David finds an amazing girlfriend . . . until she moves in with his family. If getting into college looks complicated from the outside, just imagine how wild it is for an Insider!

Customer Reviews:

Courtesy of Teens Read Too.......2007-07-03

Mickey: Has been invited to a couple of colleges to speak about his art, but at the second college he tries to mix things up and things goes awry!

Patch: He and his girlfriend, Greta, are looking for the perfect college to attend together, but they want to be on opposite coasts! And when Greta runs into an old boyfriend, can their relationship last?

Jonathan: At the first college the guys visit, Jonathan gets to see his brother, who he hasn't seen in a couple of years. And now his nerdy brother is cool?

David: He really likes his girlfriend, until she starts to feel like his sister!

Arno: He falls in love. But of course it's not that easy with the Insiders!

THE INSIDERS series seems to be dragging out, but of course you still have to love them all! How could you not?

Reviewed by: Taylor Rector

i loved it!.......2006-06-14

Mickey and Patch surprised me in this book because they know just what they want, and if they don't know, they will look for it until they find it. this book was really good, but i'm not surprised because j minter is a good author.

Book Description

The marine world harbors many attractive creatures that can sometimes lure the unwary into danger. This dramatic, full color book provides a complete photographic survey of the world's many dangerous marine animals. Practical information contained in this volume includes the biology, habitat, and unique characteristics of each species; geographic location; and prevention and treatment of injuries from each animal. Closeups and cross-sections of the venom apparatuses of many animals are also included. This book will provide a useful reference source for marine biologists, oceanographers, marine scientists, toxicologists, as well as accident, emergency, and trauma specialists. Its exciting photographs will enthrall anyone intrigued by the sea.

Toxicology of Marine Mammals (New Perspectives: Toxicology and the Environment)

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Toxicology of Marine Mammals (New Perspectives: Toxicology and the Environment)

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 0415239141

Book Description

The activities of modern society have unleashed a range of toxic chemicals into the global environment. Many of these toxicants are now being detected in increasing quantities in the tissues of marine mammals, most notably in top predators who acquire relatively large amounts of toxic chemicals by ingesting contaminated prey. Toxicology of Marine Mammals focuses on the effects of natural and introduced toxicants on organs and systems in marine mammals. It provides overviews on health status and contamination, with subsequent chapters devoted to whales, pinnipeds, dolphins, polar bears, manatees, and sea otters. Internationally renowned researchers assess the mounting evidence for adverse effects on reproduction and the chemically-induced increased susceptibility to death from infectious diseases. The concluding chapter addresses perspectives and issues for the future. This compelling book features research from a vast geographic landscape ranging from the tropics to the Arctic, with case studies on intriguing areas of contamination such as the St. Lawrence River and the Baltic Sea. It identifies the severe threats that environmental contaminants pose to the health and future of marine mammals. It also makes an urgent call for legislation to regulate the incessant pollution ravaging our seas and devastating the marine mammal population worldwide. Toxicologists working in marine biology and veterinary medicine, conservation scientists, fisheries scientists, environmental scientists, and wildlife managers will all benefit from this comprehensive resource. >Features

Book Description

Excel is by far the most widely distributed data analysis software but few users are aware of its full powers. Advanced Excel For Scientific Data Analysis takes off from where most books dealing with scientific applications of Excel end. It focuses on three areas-least squares, Fourier transformation, and digital simulation-and illustrates these with extensive examples, often taken from the literature. It also includes and describes a number of sample macros and functions to facilitate common data analysis tasks. These macros and functions are provided in uncompiled, computer-readable, easily modifiable form; readers can therefore use them as starting points for making their own personalized data analysis tools. Detailed descriptions and sample applications of standard and specialized uses of least squares for fitting data to a variety of functions, including resolving multi-component spectra; standard processes such as calibration curves and extrapolation; custom macros for general "error" propagation, standard deviations of Solver results, weighted or equidistant least squares, Gram-Schmidt orthogonalization, Fourier transformation, convolution and deconvolution, time-frequency analysis, and data mapping. There are also worked examples showing how to use centering, the covariance matrix, imprecision contours, and Wiener filtering and custom functions for bisections, Lagrange interpolation, Euler and Runge-Kutta integration.

Customer Reviews:

A source of ideas on how Excel can be used in science.......2006-09-12

This book does not give much info on Excel itself. I think the book is outstanding in that it opens one eyes to using Excel for tasks like non-linear least squares fitting of data to models, signal deconvolution, etc. In retrospect, that one could use Excel for this should not be too surprising, but I have found myself resorting to MathCAD for many of these things when a solution implemented in Excel would have been easier to share with colleagues since Excel is more available. There is a bias towards biological/chemical examples, but nothing too egregious.

Excellent advanced manual for Excel users.......2006-03-17

Every modern scientist and engineer relies upon some type of software for the analysis of data. Many software programs are available in the market today and each seems to have its own unique code and learning curve. In the PC world, perhaps no other software for data analysis is more common and easier to learn than Microsoft Excel. Many high school students are already using Excel for their homework assignments. All of these features make Excel an attractive analytical tool for scientists and engineers at university and afterwards. All such tools need reliable tutorials in order to train users to harness their full capabilities. Most available literature on Excel is introductory in nature, and therefore not appropriate for advanced applications. Robert de Levie's "Advanced Excel for scientific data analysis" helps fill in this void.

Prospective readers should be aware that this text is not appropriate for beginners. The author clearly alerts readers to this point in the preface. This is also readily apparent from browsing the Table of Contents. I was skeptical at first with some of the more advanced applications such as solving differential equations in Excel. Many scientists use higher-level programming languages such as Mathematica and Matlab to solve differential equations. While such software packages are quite powerful, they also have steep learning curves. I previously thought that Excel is not capable of solving differential equations, but Chapter 7 turned me into a believer.

The major emphasis of the examples is on least-squares and Fourier transformation. Chapter 2 does a nice job of contrasting Excel's three available routines for linear regression. The author does a very thorough job showing how Excel can be effectively used for Fourier transformation, and gives many examples. However, some other useful mathematical topics are either covered minimally or omitted entirely. For example, I was disappointed by the lack of a routine to calculate eigenvalues and eigenvectors. Excel's array structure makes it well-suited to linear algebra and the author should consider adding more on this topic in a future edition.

One of the greatest strengths of the book is its detailed coverage of Visual Basic for Applications (VBA). Advanced data analysis require the use of special user-defined functions, and VBA allows one to extend Excel capabilities to satisfy this need. Unfortunately, VBA code sometimes conflicts with Excel code. For example, the square root operation in Excel is SQRT, but in VBA is SQR. While the author certainly has no control over this, he does an excellent job alerting the reader to these pitfalls.

Chemists definitely need a reliable tool for the analysis of experimental data. de Levie's book covers most of the techniques we use in our lab. The book clearly demonstrates how Excel is not just a convenient tool for plotting data from the stock market or keeping track of students' grades, but a powerful tool for scientific data analysis. This book is highly rercommended for all students and research workers in the areas of analytical and physical chemistry.

Advanced Is Not Used Lightly in this Book's Title.......2005-07-28

If I had written this book I think I would have called it Scientific Excel rather than Advanced Excel. To be sure, the book is certainly for advanced Excel users, but it won't help you do an advanced business application.

You'd best have some knowledge about Excel before starting this one. There's a brief survey of Excel at the beginning that starts off comparing a spreadsheet to an accountant's ledger. That's pretty basic. Anyone with any Excel experience at all can follow the first three pages. On page four he is talking about making a thousand point plot with random numbers, normal distribution -- no longer something from Excel for Dummies. By page 5 he's calculating averages and standard deviations. By the end of this Survey chapter he's talking about the accuracy of the calculations performed by Excel.

Subsequent chapters discuss various types of mathematical manipulation that are often needed in the analysis of scientific data.

There are three chapters on Least Squares. This is the fitting of a curve to collected data so that the trends might be more easily visualized.

There is a chapter on Fourier Transformations, which is the probably the most frequently used analysis tool when working in signal processing. Geophysical seismic data, radar receivers, cell phone systems are all processed primarily using Fourier Transforms. This kind of data is of course too voluminous for Excel, but the techniques used here would be ideal for quite a number of laboratory applications.

A couple of chapters cover convolution, deconvolution, and time-frequency analysis as well as Numerical integration of ordinary differential equations.

All of these processing tasks are done using macros. These are described in the book, or can be downloaded from the author's website -- www.bowdoin.edu/~rdelevie/excellaneous/. This web site also includes some additional macros that enhance Excel's computationability when handling numbers of higher precision.

The final four chapters of the book are on writing your own or modifying existing macros, with an orientation to scientific analysis.

I consider this to be almost a mandatory book for anyone interested in using Excel to analysis scientific data.

Scientific number-crunching with Excel.......2005-01-07

This book by Robert de Levie is a thorough and comprehensive how-to guide to the use of the Excel program on common numerical tasks in physical science. It starts with a chapter that surveys the capabilities of the Excel program itself. It then continues with three chapters of progressively increasing sophistication on the method of least squares, followed by single chapters on Fourier transformation, convolution and deconvolution, and numerical solution of differential equations. The final four chapters are given over to the writing of macros and the author's presentation of the many macros he has developed in the course of solving the problems illustrated in the book. Readers should be aware that all of these macros, as well as the numerical data used in many of the examples, are also available in computer-readable form from the publisher's web site and, in fact, are available to purchasers and nonpurchasers alike.

I should acknowledge at the outset that I am very much NOT a fan of Excel. However, the program is by now so firmly established that there is little doubt of the value of the contents of this book to many in the intended audience of scientists and engineers. Moreover, there is also plenty of value for those of us who prefer to use computational tools other than Excel. Since my own primary interests relative to this book fall within the chapters on least-squares methods, that is where I will direct my specific comments.

As already noted, the book is about computations, not about theory, so although key working equations are often presented, they are seldom derived. Thus a beginner wanting to understand the method of least squares might want to consult another source to complement the "nuts and bolts" provided by the examples illustrated here.

Chapter 2 is devoted to the simplest of least-squares (LS) problems, unweighted fitting to a straight line (including one forced to go through the origin). This chapter also introduces the important topic of propagation of error (called propagation of imprecision by the author in an attempt to improve the terminology). A number of common applications are considered, the most important of which is probably the role of linear LS in calibration in analytical chemistry. This is, incidentally, an application where the common textbook expressions for error propagation lead to incorrect estimates of the imprecision; but de Levie "does it right."

Chapter 3 continues with linear LS, but now involving fitting to functions more complex than a straight line and often involving three or more adjustable parameters. (Note that the "linear" in linear LS refers to the manner in which the adjustable parameters occur in the fit function, not to the shape of the function itself; some authors refer to this as "multilinear.") The coverage begins with fitting to polynomials and is later extended to orthogonal polynomials. Toward the end of the chapter, weighted LS is introduced; this is needed to deal with the problem of transforming nonlinear fit relationships into linear ones, like exponentials (log transformation) and hyperbolic relationships (reciprocal transformation). Most of the examples in this chapter are from analytical and physical chemistry and are often encountered in the chemical teaching literature. These include the analysis of diatomic spectroscopic data (I2 and HCl), the analytical problem of estimating species abundances from UV-visible spectra of mixtures, and the treatment of enzyme kinetics data.

Chapter 4 turns to nonlinear LS, in which iterative methods are needed to obtain the solutions to the minimization problem at the heart of LS. The tool for accomplishing this task in Excel is the Solver routine. Solver has one glaring limitation, namely the failure to provide the statistical errors in the adjustable parameters. De Levie has solved that problem with his own macro, SolverAid. The capabilities of these routines are illustrated on a number of examples, again mostly from the realm of analytical chemistry and spectroscopy. Among the more unusual examples are fits of titration data, of discontinuous functions, and of continuous functions taken piecewise. Toward the end are included some illustrations of the performance of Solver on some benchmark nonlinear fitting problems provided by NIST (National Institute for Science and Technology).

I have personally checked many of the examples illustrated in these three chapters using other methods, and I can vouch for their general validity. In a few cases there are errors, but many of these have been corrected by the author since the first printing of the book. Users should consult the publisher's web site for a listing of these.

In summary, this work will prove a valuable addition to the bookshelves of Excel-oriented "number-crunchers." For those who prefer programs other than Excel, the examples can still provide useful instruction. For this group, the Excel material is of no use but also no real impediment. For those who hope to learn both data analysis and Excel at the same time, from "scratch," I doubt that this book will fill the bill: You'll probably need to start with more elementary treatises in both areas. I must admit that my aversion to the Excel program itself and its heavy focus in this book is what prevents me from giving the book the maximum rating.

A really advanced book on Excel.......2004-05-19

This is a remarkable book, a really advanced book on Excel, which illustrates through a wide variety of examples the extraordinary power of this modern "spreadsheet" software when exploited by a really knowledgeable user. The author is clearly an expert on spreadsheet techniques - witness his previous publications "Spreadsheet Workbook of Quantitative Chemical Analysis" and "How to Use Excel in Analytical Chemistry".
(...) In my opinion it will be mostly appreciated by postgraduate students and professionals, who will find that they can make even extremely complicated analyses of their data with full statistical cover very easily using the friendly environment of the Excel spreadsheets. (...) Therefore we can examine the accuracy and reproducibility of our data, the effectiveness of the method we use to analyse them and estimate the impact of the various errors on the final results. This is what the author almost emphatically tries to teach along with the correct application of statistics.
The great capabilities of Excel are further enhanced by the use of macros, i.e. by programming Excel to perform certain actions. (...) Moreover, it is didactic and the average reader very soon will be able to write his own macros or modify the macros of this book to suit to his interests.
As pointed out above, the capabilities and features of Excel are mainly illustrated via a wide variety of examples, which demonstrate the use of the programme for simulation of an experimental system as well as for analysis and presentation of experimental results. Most of the examples are accompanied with an extensive introduction that clarifies its physical content, quite useful since the readers may be from different scientific fields. In addition, the statistical and mathematical background at each chapter is, with a few exceptions, very good.
The book comprises 11 chapters. Chapter 1 is an introduction to Excel, although it is addressed to those who use and are familiar with Excel. It starts with a general description of spreadsheets and continues with the Excel capabilities for making 2-D and 3-D graphs. Next the complete exploitation of Excel via built-in functions, the various add-ins, custom functions and macros is extensively discussed. Finally, the use of complex numbers and matrices, the accuracy of calculations and the possibility of obtaining erroneous results are also shown. It is a useful chapter because it sums up and refreshes all the basics needed for an effective use of Excel.
Chapters 2 and 3 describe the application of the linear least squares technique starting from the simple fitting of data to a proportionality and then extending to polynomial and multivariate fittings. These methods are so easily and widely used that one can hardly be aware of the possibilities of misapplications yielding quite misleading results. The book tries to focus our attention on the correct application of the least squares technique, which means the correct selection of the dependent and independent variable, the correct selection of the adjustable parameters by means of statistical criteria and the treatment of these parameters as mutually dependent. I was impressed by the simple exercise 2.14, which shows that even the correct application of statistics may yield erroneous results, as well as by exercise 3.19 which points out that the careless application of an advanced technique, like weighted least squares, may worsen the results.
Chapter 4 describes the use of Solver for non-linear least squares and it is, in my opinion, the most interesting and useful chapter. The extensive applications of this technique are illustrated by a great variety of examples. However, this is the strength and simultaneously the weakness of this chapter. For example, one of the most useful applications of Solver is the case where the experimental and the calculated data do not correspond to common values of the independent variable. This very interesting case is described in exercise 4.4 but since this is pointed out clearly neither in the title of session 4.4 nor in the introduction of this session, it is very likely to escape from reader's attention.
Chapters 5 and 6 deal with applications of Fourier transformation in data analysis, convolution, deconvolution and time-frequency analysis. Although entire books have been written for the Fourier transformation and its application, the themes discussed here are carefully selected and clearly presented.
The numerical integration of ordinary differential equations is described in chapter 7. It is based almost exclusively on custom functions and one might be surprised by the author's choice to start with the rather unknown Euler's methods and then pass to the most popular Runge-Kutta methods. However, this is due to the author's attitude to warn constantly the reader that routine application of maths, the Runge-Kutta method in this case, may give misleading results. The chapter is completed with examples of systems exhibiting oscillations and chaotic behaviour. I think that a few pages here or in another chapter about the differentiation and integration of data would be useful.
The next chapter, chapter 8, is tutorial for writing macros. Although the author believes that earlier knowledge of some computer language is not necessary, I very strongly doubt that such a reader can follow this well-written chapter and eventually write his own macros. In my opinion this could have happened if the author had added the very basic commands of VBA, for example like those concerning control loops and conditional statements. Thus this chapter is particularly useful and very instructive for those who are already familiar with programming.
The final three chapters describe in detail the custom macros used in this book. (...)
The chapters are arranged in a logical order and establish a satisfactory balance and conformity among them. Some of them and in particular chapters 1, 7 and 8 could be more complete by including the necessary basic material that would make it unnecessary for a novice reader to consult other sources. Another minor shortcoming is that the book is not free from annoying typographic errors, though the majority of them do not confuse the reader.
To sum up, this is a valuable help for all users of Excel, highly recommended for postgraduate students and professional researchers.

Advanced Excel for Scientific Data Analysis

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Advanced Excel for Scientific Data Analysis
Robert De Levie
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback
ASIN: B000OKPFBA

Book Description

The Sand Hills of Nebraska, where Mignon G. Eberhart lived as a newlywed, inspired the setting of this 1930 chiller. Smack in the middle of the rolling desolation is Hunting’s End, a weekend lodge owned by the rich Kingery family. To that place socialite Matil Kingery invites a strange collection of guests—the same people who were at the lodge when her father died of “heart failure” exactly five years ago. She intends to find out which one of them murdered him.

Posing as another guest is the dapper young detective Lance O’Leary. At his recommendation Matil has engaged Nurse Sarah Keate to care for Aunt Lucy Kingery at Hunting’s End—not a pleasant assignment, as it turns out. Gathered at the lodge, Matil’s guests are shut off from the outside by a November snowstorm. A collie named Jericho mopes around, and a stray cat seems to herald new, clearly unnatural deaths. What a trap to spring on people used to good wine and fresh-cut flowers at dinner!

Nurse Keate is the same sharp-eyed, stiletto-tongued, strong-stomached Nightingale and sleuth who was introduced in The Patient in Room 18 and While the Patient Slept. She helped establish Mignon G. Eberhart as a mainstay of the golden age of detective fiction.

Customer Reviews:

1930's mystery.......2007-07-08

Originally written in 1930. A murder takes place in a hunting lodge. Five years later the daughter of the murder victim invites all who were there back to the hunting lodge. Unknown to the guests she invites a private detective to figure out who did the murder. Then a snow storm hits and they are all trapped inside the lodge for three days. As the detective is questioning everyone a guest dies while he is alone in his room. A mysterious note, poison missing from the pantry, a radio that will not work. This book was very well written. If you enjoy Agatha Christie mysteries you will also enjoy this mystery.

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The Mystery of Hunting's End
M.G. EBERHART
Manufacturer: William Heinemann
ProductGroup: Book
Binding: Hardcover
ASIN: B000PRQ0VQ

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The Mystery of Hunting's End
Mignon G. Eberhaet
Manufacturer: Popular Library
ProductGroup: Book
Binding: Paperback
ASIN: B000SQX8RI

Product Description

Eirie atmosphere, suspense, exitement, mystery and murder maybe with exciting clues

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The Mystery of Hunting's End
Mignon Eberhart
Manufacturer: Popular Library
ProductGroup: Book
Binding: Mass Market Paperback
ASIN: B000UXDGLC

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The Mystery of Hunting's end
M.G. Eberhart
Manufacturer: Aeonian Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000ND7XEA

Rendez-vous De Chasse (("Hunting's End"))

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Rendez-vous De Chasse (("Hunting's End"))

Manufacturer: Librairie Des Champs-Elysees, Paris
ProductGroup: Book
Binding: Paperback

All French Books | French | Foreign Language Books | Specialty Stores | Books
ASIN: B000F6NAGU

Product Description

small thick square orange,black&white paperback,1972 Librairie Des Champs-Elysees Publ,Paris France,in french,a mystery,252pages

American Hunter Video Collection, 15 VHS Tape Set Plus 5 Collector's Series Coins!! (Set Includes-Whitetail Challenge VII, Whitetail Mysteries and Madness, Hunting Adventures:To the Extreme, Adventures Across North America, Dream Bucks, Pure Whitetail:Chance of a Lifetime, Wild Endeavors, Big Game Madness, Dream Season, Strategies For Success, Whitetail Extreme, Hunting The Outer Limits, Hunting Mature Whitetails:Upper End Mangement, Whitetail Frenzy and the 5 piece coin set.)

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American Hunter Video Collection, 15 VHS Tape Set Plus 5 Collector's Series Coins!! (Set Includes-Whitetail Challenge VII, Whitetail Mysteries and Madness, Hunting Adventures:To the Extreme, Adventures Across North America, Dream Bucks, Pure Whitetail:Chance of a Lifetime, Wild Endeavors, Big Game Madness, Dream Season, Strategies For Success, Whitetail Extreme, Hunting The Outer Limits, Hunting Mature Whitetails:Upper End Mangement, Whitetail Frenzy and the 5 piece coin set.)
National Rifle Association
Manufacturer: National Rifle Association
ProductGroup: Book
Binding: Audio Cassette
ASIN: B000PT9U8Y

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