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Creating Philanthropic Capital Markets: The Deliberate Evolution
Lucy Bernholz Manufacturer: Wiley ProductGroup: Book Binding: Hardcover Similar Items:
ASIN: 0471448524 |
Book Description
Through a coherent framework for pursuing such far-ranging changes, this easy-to-understand book addresses new ways for individuals and organizations to invest grant funds, approach regulatory structures that guide giving, and define their goals, activities, outcomes, and achievements. The author applies basic principles of industrial theory and evolution to examine, with a trained scholar’s eye, how individual organizations, associations, and the philanthropic infrastructure can work more effectively.Order your copy today!
Download Description
This book applies the basics of industrial theory and evolution to see how individual organizations, associations, and the philanthropic infrastructure can change to work more effectively--suggesting how to build a framework for philanthropy as it must develop as an industry through the 21st century. It includes a thorough breakdown of industry drivers (e.g., demographic changes, wealth and income predictions and disparities, regulatory pressure, and new technologies) and offers practical advice for the development of a new capital market based on such opportunities as organizational change (new staffing patterns), new uses for industry knowledge (technological advances), and the advent of tangential service providers (consultants and advisors).
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The Restaurant Survival Bible: An Insider's Guide to Successful and Profitable Restaurant Ownership
William J. Durkin Manufacturer: Writers Club Press ProductGroup: Book Binding: Paperback ASIN: 0595140831 |
Book Description
This book is for all those who ever contemplated owning or are in the midst of running their own restaurant business.
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The Small Business Bible: The Make or Break Factors for Survival and Success
Paul Resnik Manufacturer: John Wiley & Sons ProductGroup: Book Binding: Paperback ASIN: 0471629855 |
Customer Reviews:
Great basic Small Business guide: .......2006-12-08
The Best in Small Business Basics.......2000-01-11
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The Music Business Bible Survival Kit
Vaughan Mason Manufacturer: Funky Feet Publishing, Co. ProductGroup: Book Binding: Perfect Paperback ASIN: 0615135870 Release Date: 2006-12-27 |
Product Description
Vaughan Mason's detailed account of all the illegal and legal Sh*t that goes on to make you a star and rich in the Music Business. No Bullsh*t!
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Business Bible for Survival
A. David Silver Manufacturer: Prima Lifestyles ProductGroup: Book Binding: Paperback ASIN: 1559580097 Release Date: 1994-12-31 |
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Recollections of a Pacific Entomologist 1925-1966 (ACIAR Monographs)
R.W. Paine Manufacturer: Australian Centre for International Agricultural Research ProductGroup: Book Binding: Paperback ASIN: 1863201068 |
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Life Evolving: Molecules, Mind, and Meaning
Christian de Duve Manufacturer: Oxford University Press, USA ProductGroup: Book Binding: Hardcover Similar Items:
ASIN: 0195156056 |
Book Description
In just a half century, humanity has made an astounding leap in its understanding of life. Now, one of the giants of biological science, Christian de Duve, discusses what we've learned in this half century, ranging from the tiniest cells to the future of our species and of life itself. With wide-ranging erudition, de Duve takes us on a dazzling tour of the biological world, beginning with the invisible workings of the cell, the area in which he won his Nobel Prize. He describes how the first cells may have arisen and suggests that they may have been like the organisms that exist today near deep-sea hydrothermal vents. Contrary to many other scientists, he argues that life was bound to arise and that it probably only took millennia--maybe tens of thousands of years--to move from rough building blocks to the first organisms possessing the basic properties of life. With equal authority, De Duve examines topics such as the evolution of humans, the origins of consciousness, the development of language, the birth of science, and the origin of emotion, morality, altruism, and love. He concludes with his conjectures on the future of humanity--for instance, we may evolve, perhaps via genetic engineering, into a new species--and he shares his personal thoughts about God and immortality. In Life Evolving, one of our most eminent scientists sums up what he has learned about the nature of life and our place in the universe. An extraordinarily wise and humane volume, it will fascinate readers curious about the world around them and about the impact of science on philosophy and religion.Customer Reviews:
One giant leap of faith after another.......2004-04-27
Unfortunately, the book delivers neither.
As another reviewer pointed out already, De Duve divulges the reader into the basics of cell biology; a nice introduction of life chemistry, proteins, RNA, DNA, enzymes and such.
De Duve then spends few chapters on paving the way from a pre biotic world to one that is dominated by protocells. He believes that proteins are a by-product of RNA and therefore RNA must have preceded proteins. Judging by the complexity of RNA, he postulates that peptide bonds _somehow_ formed among amino acids with the help of what he calls "multimers" (amino acids among other things), and those short peptides could have played the role of a primitive catalyst.
What De Duve fails to provide through out his book is data + examples. To convince any reader with the possibility of such event, common wisdom dictates a minimum amount of experimental data to support the "building" blocks of his hypothesis.
In 1997, Ghadri group synthesized a peptide ligase. That is, a self-replicating 32 amino-acid long peptide. It is the constant lack of evidence that makes Du Duve arguments weak.
Then he says that ATP and other NTPs _somehow_ arose, and the discussion for their "existence" is beyond the scope of the book. Then our catalyst peptide forms an RNA-like structure from ATP and others. Then he says that many bases were initially bound, not just A, U, G, and C. But once we had a "rare" RNA with A, U, G, C, it is _somehow_ more stable and more reproducible. De Duve does not really discuss why he believes this is the case, other than it must be because this is what we have now.
In one occasion, De Duve says "Admittedly, this is all hypothetical. But the hypothesis rests on undeniable foundations and has the advantage of suggesting experimental approaches". He made it clear on several occasions than many areas of pre biotic chemistry lack experimentation despite their significance in origin-of-life research. After suggesting an experiment, he concludes "This is what I would do if I were 20 years younger".
De Duve then goes on to explain how the RNA led eventually to proteins (RNA attaches itself to some amino acids, and using the RNA itself as a catalyst, we form protein). And that once we had proteins, life needed cells at that stage to compete and protocells were created. The RNA made proteins, and RNA that made better proteins for the cell survived and got duplicated. The cell at this has some rudimentary membrane, and can replicate itself via division.
What he skipped is how such membrane forms, why it forms, and how the division process in this protocell exactly takes place.
I really wished that De Duve paid more attention to such critical details. Different people might read the book for different reasons, I read it for the goal of gaining an understanding on abiogenesis. Being a strong believer in abiogenesis myself, I was quite enthusiastic when I began reading the book. However, skepticism over Duve's take on abiogensis kept growing as I read more chapters.
Unfortunately, I lost faith in his approach to this critical issue.
Interesting and thought provoking book.......2003-01-28
De Duve gives a great review of just how cells work at the molecular level. There is adequate depth without getting bogged down in details. What I really wanted to see was his explanation for the origin of life. De Duve proposes that
Abundant triphosphates somehow arose to provide energy
Prebiotic peptide catalysts somehow arose
Myriads of different RNA-like molecules somehow formed from phosphates
"Rare true-RNA" molecules evolved by Darwinian evolution
RNAs began to make proteins out of the abundant amino acid soup
The RNAs began to make cell walls
The genetic code for specific proteins arose via Darwinian evolution
These very short RNA chains grew tremendously longer via Darwinian evolution
DNA developed from RNA to form protocells
The protocells evolved via Darwinian evolution until they became the first living cells
The key to his proposal is molecular selection. "This mechanism, it must be emphasized, represents at the molecular level exactly that imagined by Darwin to account for biological evolution". In other words, the way to get around the incredible odds of accomplishing each of the proposed steps to life listed above is by having non-living molecules competing with each other. The winning molecules then advance to the next level of competition.
De Duve is rather less than kind to those who disagree. He is distressed that many intelligent people, even scientists, do not agree that this is a plausible explanation to the origin of life. As one with a background in the earth sciences, I am one of the skeptics. My major problem is that he seemingly ignores data from other scientific disciplines. His premise depends on assumptions that are either wrong or improbable at best.
His proposal requires a benign chemical environment with a rich prebiotic soup from which the peptides, RNAs, and proteins could form. Geochemists and planetary physicists have conclusively demonstrated that this soup simply didn't exist. The neutral atmosphere of the early earth could not form prebiotics. In addition, there was sufficient photogenic oxygen in the atmosphere and radiogenic (radiation-induced) oxygen in the oceans to destroy them if they did form. No "prebiotic soup" has ever been found, although "post-biotics" are extremely common. What does exist in abundance are deposits of poisonous heavy metals and rare-earth elements. The early ocean more closely resembled the deadly effluent from a toxic waste dump than the prebiotic soup De Duve needs. Entire industries exist to mine these materials which were once poisons dissolved in the early oceans.
De Duve proposes that prebiotic materials were delivered to the Earth from outer space. Small amounts of nucleic acids have been found in some meteorites, and comets often contain some carbon compounds as well. In reality, the volume of chemicals is small, but the energy release is not. For example, the Shoemaker-Levy comet which struck Jupiter in 1994, probably contained hundreds of tons of organic compounds. This is the proverbial "drop in a bucket" in terms of getting a meaningful volume of prebiotics into the ocean. However, the impact event was roughly 100 million megatons of TNT. This is ten thousand times the power of all of mankind's nuclear weapons combined. We would all be dead if this impact had occurred on Earth.
Another problem occurs in obtaining concentrated baths of organic compounds. The scenarios De Duve mentions are Darwin's "warm little pond" and Stanley Miller's "drying lagoon". These are physical impossibilities on the early earth, where tides were measured in hundreds of feet and wind speeds were measured in thousands of miles an hour. Think of the movie "Perfect Storm" and consider that the weather never got that nice 3.9 billion years ago! There is no plausible mechanism available to generate a concentrated bath of prebiotic compounds in such an environment.
The last several chapters delve into esoteric astronomical subjects far from De Duve's area of expertise, including life on other planets. Large numbers are quoted, but there is little discussed in the vein of cause-and-effect from which a meaningful statistical calculation could be made. He acknowledges that the physical properties of the universe exhibit evidence of incredible precision which allows life to exist. Inconceivably tiny deviations in a number of parameters would make life impossible. This "anthropic principle" has led many formerly atheistic or agnostic scientists to a belief in God. I know one radio-astronomer who wrote "Astronomers who do not draw theistic or deistic conclusions are becoming rare", while his atheist collegue complained that his fellow astronomers are rushing off to join "the First Church of Christ of the Big Bang." De Duve apparently prefers the explanation that there are an infinite number of universes, perhaps even evolving via natural selection, and ours is the lucky one.
De Duve's final appeal is that "something positive must be proposed that can eventually replace the myths propagated by religion." God does not exist, but we need "spiritual guides" to provide ethics and morals. "The religious feeling is deeply embedded in our nature, probably carved into it by natural selection"
I enjoyed De Duve's excellent description of cellular biology. However, I found his proposed mechanisms for the origin of life unconvincing and unsupported by actual chemical pathways. He ignored the hard evidence from other scientific disciplines that render his explanations highly implausible. His premise that science has demonstrated naturalistic explanations to how the universe, the earth, and mankind got here requires more faith than I can muster. I remain skeptical, and tend to agree with the astronomers, who are finding increasing evidence of "something else behind it all".
Intellectually Engaging.......2003-01-28
However, evolutionary convergence shows that the history of life is not as contingent as some critics of de Duve's positions would argue. Quite surprisingly, the author does not discuss any cases of molecular convergence in Life Evolving. The small, but very revealing, list of known examples includes the independent development of biosynthetic pathways for molecules such as lysine or the imizadole moiety found in purines and histidine as well as the polyphyletic origin of several nonhomologous classes of nucleic acid polymerases. With only one example of biology (Earth's own) we cannot calculate probabilities, but the search for extraterrestrial life may assist us in evaluating the evolutionary odds of life and consciousness. The idea that life on Earth is the result of a miracle or of a rare chance event has been replaced by an evolutionary narrative. Still, as William Blake wrote in There Is No Natural Religion, "Reason, or the ratio of all we have already known, is not the same that it shall be when we know more." The discovery of dozens of planets orbiting nearby stars and the prospect of searching for compounds of possible biological origin in their atmospheres suggest that in the not-so-distant future we may have more factors to consider when addressing the issues de Duve raises.
Whether or not one agrees with de Duve's strong statements, Life Evolving forces the reader to avoid intellectual complacency and to articulate one's own arguments to effectively address his position. These are, in themselves, major reasons to appreciate the book.
Examines how humans have evolved and developed.......2003-01-10
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Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Physiology (Cabi Publishing)
Manufacturer: CABI ProductGroup: Book Binding: Hardcover ASIN: 0851990274 |
Book Description
This book examines recent research into the molecular biology, genomics and transcriptomics of, and novel control strategies for, flatworm parasites. These include Cestodes (tapeworms) and Trematodes (flukes, schistosomes etc), which are the cause of a number of diseases of medical and
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The Physiology and Biochemistry of Cestodes
J. D. Smyth , and D. P. McManus Manufacturer: Cambridge University Press ProductGroup: Book Binding: Paperback ASIN: 0521038952 |
Book Description
This is an updated and expanded version of Professor Smyth's earlier work The Physiology of Cestodes (1969) which presented for the first time an overview of the physiology of these parasitic worms, many species of which cause serious, often fatal, diseases in man and domestic animals. Recent advances in investigative techniques, such as immunocytochemistry and in vitro culture, which have increased immensely our understanding of these organisms, are presented. The biochemical coverage has been expanded to include the spectacular advances in molecular biology in recent years. The book also shows how cestodes are increasingly being recognized as valuable models for transport and cell differentiation. Medical and veterinary students as well as students in parasitology and zoology will find this book an invaluable resource.
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Effects of phytochemicals of Flemingia vestita (Fabaceae) on glucose 6-phosphate dehydrogenase and enzymes of gluconeogenesis in a cestode (Raillietina ... Biochemistry and Physiology, Part C]
B. Das , V. Tandon , and N. Saha Manufacturer: Elsevier ProductGroup: Book Binding: Digital ASIN: B000RQZL1K |
Book Description
This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
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Montana Fly Fishing and Camping Guide
David Archer Manufacturer: Glaciertoyellowstone.Com ProductGroup: Book Binding: Paperback Similar Items:
ASIN: 0967080614 |
Book Description
Pick a spot between Glacier National Park and Yellowstone National Park and ready yourself for more fishing than you can possibly imagine. This comprehensive guide to the best fly fishing and camping in Montana is user friendly. Maps are provided for each section, along with a map for each of the two parks. Select a highway or secondary road, open up the book to your starting point, and follow the mileage marker signs to river access points, as well as those wonderful streams and small lakes that are seldom visited.Fishing in Glacier National Park and Yellowstone National Park is thoroughly covered. Between the two parks the book divides into six sections: Northwest, Western, Rocky Mountain Front, Upper Missouri River, Southwestern and the Yellowstone River drainage. Montana's famous rivers are covered: Beaverhead River, Big Hole River, Big Horn River, Bitterroot River, Blackfoot River, Clark Fork River, Flathead River, Gallatin River, Kootenai River, Thompson River, Swan River, Yellowstone River, and the Yaak River. In addition, over 50 creeks and little known rivers are covered along with a multitude of backcountry lakes that may be reached in a day hike.
Archer's book is "organized the same way people get to fishing holes -- by the highway that leads them there....The chapters are based on highways, and mileage marker information leads readers right to the holes...." - Nick Gevock, Missoulian
Customer Reviews:
Designed For Flyfishers Who Camp.......2007-05-16
Makes planning your trip easy. Adventure stories add to fun........2005-05-04
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Montana Fishing and Camping Guide - Glacier to Yellowstone
David Archer Manufacturer: Glaciertoyellowstone.com ProductGroup: Book Binding: Paperback ASIN: 0967080606 |
Book Description
Glacier to Yellowstone provides a comprehesive Montana camping and fishing guide stretching between Montana's two great national treasures. The book divides up the area between the two parks in three sections: northwest, western and southwestern. Fifteen maps are provided along with these famous rivers: Beaverhead River, Big Hole River, Bitterrot River, Blackfoot River, Clark Fork River, Flathead River, Gallatin River, Kootenai River, Madison River, Thompson River, Swan River, Yellowstone River and the Yaak River. Fishing in both parks is covered as well as directions and information to over 50 creeks and lesser known rivers. If you like to fish back country lakes, select one of over a 100 offerings from Glacier to Yellowstone.The book is replete with photographs, and detailed information is provided for fishing specific waters. Icon symbols and mileage marker designations provide quick reference while you are traveling. A section, "Accommodations and Services" is provided for each of the three regions.
Customer Reviews:
Even for a Montana native, truly enjoyable.........2000-06-14
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You Can Find Anybody!
Joseph Culligan Manufacturer: Jodere Group ProductGroup: Book Binding: Hardcover Similar Items:
ASIN: 1588720004 Release Date: 2000-11-01 |
Book Description
Right at your fingertips, you can now have access to thousands of government and law enforcement agencies, records departments, and licensing bureaus used by private detectives! Renowned private investigator Joseph Culligan has done all the legworkall you have to do is pick up this book and find the information you need.Customer Reviews:
Don't Waste Your Money..........2005-06-29
Good for adoption searches too!.......2004-10-26
You, Too, Can Find Anyone.......2000-04-03
A Genealogist's Best Friend.......1999-12-20
I currently have the 1994 edition, but I'm definitely purchasing the lastest edition.
A great help in getting the ball rolling on any search.......1999-08-01
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You, Too, Can Find Anybody
Joseph J. Culligan ProductGroup: Book Binding: Paperback ASIN: B000RBKNLI |
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You, Too, Can Find Anybody: A Reference Manual
Joseph J. Culligan Manufacturer: Research Investigative Services ProductGroup: Book Binding: Paperback ASIN: B000J4I0AY |
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Art of Hand-Lettering Its Mastery and Practice
H. Wotzkow Manufacturer: Dover Publications ProductGroup: Book Binding: Paperback ASIN: 0486217973 |
Customer Reviews:
The Art of Hand-Lettering Its' Mastery and Practice.......2005-09-13
A Good Addition to any Typographer's Library.......1998-02-22
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The art of hand-lettering, its mastery & practice
Helm Wotzkow Manufacturer: Dover Publications ProductGroup: Book Binding: Unknown Binding ASIN: B0006BQONA |
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The art of hand-lettering, its mastery & practice
Helm Wotzkow Manufacturer: Watson-Guptill Publications ProductGroup: Book Binding: Hardcover ASIN: B000O2NQIM |
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